The "it must be genetics" conclusion is understandable. If multiple products over multiple years have produced no visible change, a permanent explanation starts to feel like the only plausible one.
But research into follicle biology paints a more nuanced picture.
Follicle dormancy, the state in which a follicle stops producing hair, is a normal part of the hair growth cycle. Follicles cycle through active growth phases (anagen), transitional phases (catagen), and resting phases (telogen). For most follicles on a healthy scalp or facial hair region, this cycling is self-regulating and continuous.
In some cases, follicles can enter an extended dormant state, remaining technically present and viable in the dermis but inactive for months or years. This is distinct from follicle miniaturisation (associated with androgenic alopecia, a separate condition with different characteristics and different progression patterns) and distinct from follicle loss entirely.
For men with patchy beards, particularly those who haven't experienced sudden or progressive thinning but have simply always had gaps in certain areas, the dormant follicle explanation is often more consistent with what's actually happening than permanent absence or genetic programming.
The key question is: what signals follicles to re-enter the active growth phase?
Research points to several mechanisms: adequate blood circulation to the follicle region, specific peptide signals that interact with follicle receptors, and the presence of certain botanical compounds that have been studied for their effects on follicle activation. These aren't speculative mechanisms, they're the basis of the serious end of the topical beard and scalp growth research.
The challenge is getting those signals to the follicle, which sits 4mm below a barrier that most products were never formulated to cross.